IDK, depends on the CPU architecture... I'm not that famlilar with Macs, but if it's x64 capable, yeah, no problem.
I think there was a list of supported architectures on the website 🤔...
Can't find it now. Anyway, x86, x86_64, ARMv6/v7/v8 are all supported out of the box. PPC is also supported, but you have to build everything yourself from scratch (there was one maintainer that maintained a PPC build, but he gave up on it a year or so ago, he went on to form Chimera Linux), which can be done by crossbuilding on any of the supported architectures using xbps-src... but that's a lot of work to be honest, if it's a PPC architecture, you're better off using Chimera Linux.
I do recommend trying the glibc version first, since you'd have to run everything that depends on glibc in a chroot, on a musl install. Yeah, it is doable, but if you're not really experienced with this, just use the glibc version.