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TheRealKuni ,

There’s good reason to be snobby about antihistamines. Second and third generation antihistamines are straight-up better than first generation. No drowsiness and they last longer.

Diphenhydramine, for example, is pretty terrible. The FAA doesn’t let pilots fly for 60 HOURS after taking diphenhydramine because of how impairing it can be without the user realizing. Extended use of anticholinergics has also been linked to dementia, IIRC.

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