I've got uBlock and Privacy Badger but turning them off or going incognito doesn't help at all. The most common issue I get with YouTube is the video keeps freezing. Apparently this is because Google deliberately fuck it so that other browsers have to play catch up constantly. I have heard this is why Microsoft gave up and adopted Chromium.
The other issue is that if I open more than one YouTube tab my laptop sounds like it is about to take off into space. I can have an unlimited number of tabs from any other website open though.