For my threat model, yes they are trustworthy enough. I am not concerned about concealing my identity from a government investigating me for some alleged crime, but rather just transitioning away from Google and investing my time and money into a company that better respects my privacy. As a result, the centralisation doesn't concern me as much as it does others and I am fine using Proton for VPN, email, calendar and storage. I also use SimpleLogin, which is now owned by Proton. All their applications are well designed and reliable for basic use in my experience, and it is more affordable for me to bundle these services together. I would definitely recommend them to people like myself, but your threat model sounds a little more complicated so you might want to do some further research and see what else is out there.