Truenas scale is Debian, if you just use it remotely it may be a good bet. If you may use the server as workstation (e.g. desktop) then you better use Debian itself (or both, as VMs under Proxmox). Managing ZFS is super easy, just create a couple of volumes with small and big blocksize, in either cockpit or whatever web ui. You may also switch OS (e.g. disaster or play around), and recover these effortlessly with zfs import command from CLI. Good luck!