I support an engineering org server, they access their files via nextcloud with a mariadb server and redis, plus some caching stuff for php-fpm, and an nginx front-end.
No complaints, checks (from what I see) all your boxes and has been very dependable going on 6 yrs now for all their simulation data both large and small off a little 1gbps dell r710.
Don't install a lot of plugins. The setup documentation seems to be just right, getting you to the ideal destination of reliable and fast. Do take the option to run tasks in crontab, instead of internally.