Well I cant say specifically to your setup. But I have an old server that I use as a hypervisor running Proxmox. On it I have an OPNsense VM Ive been running for years now. I dont do any crazy pass thru stuff. I just added each NIC as a normal network device bridged to the specific hardware port. I also use it as a Reverse Proxy for all my internal service such as Emby.