Wouldn't do it for a litany of reasons, but the main being that it's not meant for such things. You want it to be as close to the OS and drivers as possible. Anything getting between Unraid managing the disks is overly complex, and asking for trouble. What happens if the container dies? What happens if the container gets OOMkill'd?
If you're not going to use it to manage your disks, then I guess no issues, but there's better suited software for such things.