I’ve recently tried to do that using sunsine and different linux gaming distros and it was awful, the VM was working great for a few minutes and then suddenly crashes and I have to hard stop it.
Are you running this with something like libvirtd/qemu? If so, VFIO configurations can get pretty complex. Random crashes seem like MSI interrupt issues (or you've allocated too much RAM to the guest). Or it could be GPU reset issues that would also occur on the (Linux) host, a newer kernel and Mesa version in the guest may help.
Setting on the kernel commandline for the host to workaround MSR interrupt crashes:
kvm.ignore_msrs=1
If you're running on a Windows host or with something like Virtualbox (assuming GPU passthrough is supported by these), YMMV but I wouldn't expect good results.