not memes for me but anime. there's no way to block whole instances i don't wanna see. if i don't wanna see ani.social on my feed at all i have to block every community on the instance, which is just not possible.
memes though is gonna be hard for you because a lot of people use meme formats to communicate in any topic. the science side of lemmy memes about science stuff. the programmers meme about computer stuff. but that's not all they do, there's more than just memes, there's actual discussion too. to completely get rid of memes and never see them on a lemmy feed again is gonna be an impossible task.