Eh? Nothing significant has changed about the windows file system in over a decade, at least not from a user standpoint.
Most people don’t need to muck about in ProgramData, Program Files vs Program Files (x86) is pretty minimal, though admittedly you may need to check both if you’re unsure which the app you’re using is. I suppose %appdata% has changed, and one could argue it was significant, but in all honesty the concept of local vs remote should get you where you’re going, and worst case you check both.
But the base directory structure has been pretty static for a long while now.