They are extremely toothless in the sense of making continuation of the war less interesting.
Russian oil\gas\etc revenues have grown.
What the sanctions have hurt are mostly many smaller businesses and individuals. Well, big companies too, but that just makes them more dependent on state support. Which is a win for the Russian government.
Kaspersky is definitely an FSB-friendly company.
But still, most people hurt by sanctions are innocent. Well, less guilty than European politicians profiting from cooperation with Russia both before and after 2022, and remember how all those "free democratic" countries claimed Russian elections were legit when having Putin in Russia seemed to have no downsides, despite mass protests.