AstroForge thinks they can close the business case for asteroid mining. Their concept is to launch mining satellites to near-Earth M-type asteroids to mine platinum group metals. These would go on 2 year missions to bring back $100 million+ in metal at a time. With launch and satellite costs dropping, it might just work. Their forge demo sat has been struggling but moving forward. Their asteroid flyby demo sat should launch later this year.
Redwire 3d printed a meniscus in space last year. That'll take awhile to get worthwhile scale and cost, but it's another interesting avenue.
Varda hit regulatory trouble, but their orbital drug manufacturing demo did its job.