It's a r/bonehurtingjuice meme (a little like an anti-meme, but bonehurtingjuice takes memes and recontextualises them).
The original comic it's referencing shows an air hostess asking someone to turn off a tablet for takeoff. An older man, holding a book, chimes in with 'I guess I don't have to turn mine "off" eh? Ha! Heh heh.'
The laugh in particular is so off kilter and strange it became a meme in itself, a very persistent one used in tons of other bonehurtingjuice memes.
