They use the 4 male leads to make fun of nerdy, generally neurodivergent coded people. One of the leads is an unrepentant asshole and the show seems to argue that he must be an asshole because he's autistic, though they never explicitly state that.
If you happen to be neurodivergent, and grew up being harassed for expressing some of the same traits represented by those characters, the show leaves an all too familiar, very bitter taste. All the while acknowledging that those characters grew up in exactly the same circumstances the show seeks to recreate for laughs.
If you're a neurodivergent person, the show is saying to you that "you have trouble fitting in in the society you live in, that we've created, and that's funny to us."