Loss refers to parodies of an old, exceptionally cringe webcomic strip, where the joke eventually turned to making the four panels more and more abstract until it became four lines with one horizontal.
Here’s my best shot at explaining. Unlike my grandma, you’ll know more about video game and internet culture already :)
The character is Alyx from Half-Life 2. “Source Filmmaker” is an app that lets you pose and animate characters from Valve games and is frequently used for meme videos. It was likely used to pose Alyx’s face this way.
The meme pokes fun at the “elitist” attitude many people with air fryers had, as they swore by using them for everything. A key trait is the smirk expression the person in the picture has.